| 21.02.2022 | 14:30 | Manisa FK | vs | Ümraniyespor | beIN SPORTS MAX 1 , TRT Spor |
| 21.02.2022 | 17:00 | Adanaspor | vs | BB Erzurum | beIN SPORTS MAX 1 , TRT Spor |
| 21.02.2022 | 20:00 | Göztepe | vs | Galatasaray | beIN SPORTS 1 |
| 21.02.2022 | 20:00 | Eyüpspor | vs | Menemenspor | beIN SPORTS MAX 1 , TRT Avaz |
| 21.02.2022 | 20:00 | Altınordu | vs | Bandırmaspor | beIN SPORTS MAX 2 , TRT Spor |
| 21.02.2022 | 21:00 | Cagliari | vs | Napoli | S Sport Plus , S Sport 2 |
| 21.02.2022 | 22:45 | Toulouse | vs | Le Havre | beIN SPORTS 2 |
| 21.02.2022 | 23:00 | Celta Vigo | vs | Levante | Spor SMART |
| 21.02.2022 | 23:00 | Bologna | vs | Spezia | S Sport Plus , S Sport 2 |
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